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KMID : 1094020190360010046
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Journal of Veterinary Clinics
2019 Volume.36 No. 1 p.46 ~ p.52
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Pharmacokinetics and Pharmacodynamics Following Oral Administration of Pimobendan-Pentoxifylline Powder Formulation Mixture in Dogs
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Ro Woong-Bin
Song Doo-Won
Kang Yeo-Lim
Park You-Jin
Yoo Cho-Rong
Lee Jong-Ho
Kim Ki-Hun
Jeong Sang-Hee
Kang Min-Hee
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Abstract
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Pimobendan has inotropic and vasodilating effects on cardiovascular system, and pentoxifylline is known to decrease blood viscosity and improve blood flow to the heart. This study investigated the pharmacokinetics and pharmacodynamics following oral administration of pimobendan-pentoxifylline powder mixture in dogs. Eight healthy dogs were included and were divided into control (n = 4) and experimental (n = 4) groups. Vehicle powder and pimobendan-pentoxifylline powder mixture (pimobendane 0.25 mg/kg, pentoxifylline 15 mg/kg) were administrated orally to control and experimental groups, respectively. Plasma samples and measurement of echocardiographic indices were obtained for 24 hours following administration. Pimobendan and pentoxifylline concentrations were investigated using liquid chromatography-mass spectrometer (LC-MS) assay. The elimination half-life (T1/2) were 2.65 ± 1.42 hours for pimobendan and 0.29 ± 0.23 hours for pentoxifylline. The time to reach maximum concentration (Tmax) were 1.08 ± 0.72 hours for pimobendan and 0.29 ± 0.14 hours for pentoxifylline. The maximum blood concentration (Cmax) were 2.83 ± 1.50 ng/mL for pimobendan and 1184.33 ± 932.37 ng/mL for pentoxifylline. Among echocardiographic indices, fractional shortening (FS), left ventricular internal diameter at end systole (LVIDs), and pre-ejection period (PEP) showed significant changes at 1-4 hours after the administration of pimobendan-pentoxifylline powder mixture. No adverse effects were observed during the investigation. This study demonstrates that pimobendan-pentoxifylline powder mixture can be used to control cardiovascular diseases in dogs.
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KEYWORD
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Pimobendan has inotropic and vasodilating effects on cardiovascular system, and pentoxifylline is known
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